About this event
- Date and time Tue 30 Jan 2024 from 8:30am to 31 Jan 2024 at 5:05pm
- Location Royal Society of Medicine
- Organised by Pathology, The Pathological Society of Great Britain and Ireland
Join us for this stimulating event to explore the role of pathology in underpinning personalized and precision medicine. Cutting-edge techniques, such as single cell analyses, computational pathology and artificial intelligence, will be explored to enable an understanding of how the data acquired from tissue interrogation translate into patient management.
This meeting is a fantastic opportunity to hear from and talk to researchers who are world-renowned experts in their field as well as connect and network with your peers.
By attending, you will:
- Learn about the latest theories on the evolution of cancer
- Understand how the immune response can be manipulated to destroy tumour cells
- Explore how AI can extract biologically and clinically relevant information from histological images
- Understand how information from single cells and their location can inform disease biology
- Learn about the genetic basis of non-neoplastic diseases
If you would like to submit an abstract, please submit your abstract application using this form. Top scoring abstracts will be selected for Plenary sessions and Rapid fire presentations. Deadline: 11:59pm on Friday 3 November 2023 (please note: this deadline will not be extended)
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We would like to thank our sponsor Proscia for their support of this meeting. Please note that the main scientific programme and content has not been influenced in any way by the sponsor.
Agenda
Day 1 - View the programme 30 January 2024
Guy Whittle Auditorium
Unless otherwise stated, talks are 25 minutes, plus 5 minutes for questions and answers
Registration, tea and coffee
Welcome and introduction
Professor Elizabeth Soilleux, Department of Pathology, University of Cambridge
Symposium 1: Multifocal origins of cancer
Chairs: Professor Ming Du and Professor Mark Arends
Leukaemia: Clonal haematopoiesis and myeloid cancer prevention
Professor George Vassiliou, Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre
T(14:18)/IGH::BCL2 drives clonal lymphomagenesis with multi-malignant potential
Professor Ming Du, Department of Pathology, University of Cambridge
Lung cancer: Mechanisms of tumour development
Dr David Moore, Consultant Thoracic and Molecular Pathologist, University College London
Tea and coffee break
Poster Viewing and Trade Exhibition
Symposium 2: Immune responses to cancer
Chairs: Professor Elizabeth Soilleux and Professor Mark Arends
Can circulating T-cells be used for the early detection of Isocitrate Dehydrogenase (IDH1) mutant gliomas?
Dr Jamie Blundell, Assistant Professor, Department of Pathology, University of Cambridge
Weaponising T-cells to intercept lung carcinogenesis in smokers
Dr James Reading, Group Leader, Pre-Cancer Immunology Lab, University College London Cancer Institute
Lunch
Poster Viewing and Trade Exhibition
1:00pm - Poster rounds
Plenary sessions
Tracking T-cell clonal dynamics across time and space in metastatic colorectal cancer
Ann-Marie Baker
DCIS-associated myoepithelial cells drive transcriptional alterations in macrophages through up-regulation of integrin
Louise Jones
Characterisation of HER2-Enriched signature in breast cancer and prediction of the risk of recurrence using fine morphometric features
Nehal Atallah
Timing copy number alterations in Barrett's oesophagus in absolute time
Calum Gabbutt
Spatial transcriptomic profiling reveals novel biomarkers in EBV+ lymphoproliferations with Hodgkin-like features: The next generation of diagnostics.
Matthew Pugh
Multi-regional profiling of rare non-small cell lung carcinoma subtypes
Oliver Shutkever
Tea and coffee break
Poster Viewing and Trade Exhibition
Announcements
Jeremy Jass Prize for Research Excellence in Pathology
Goudie lecture: A glutton for punishment - the liver and its response to injury
Dr Timothy Kendall, Senior Clinical Research Fellow in Pathology, University of Edinburgh
Closing remarks
Close of meeting
Dinner at 100 Wardour Street
Presentation of Plenary Prize and Poster Prizes
Location: 100 Wardour St, London, W1F OTL
Registration closes: 25 January 2024
Dress code: Smart casual
Day 2 - View the programme 31 January 2024
Guy Whittle Auditorium
Unless otherwise stated, talks are 25 minutes, plus 5 minutes for questions and answers
Registration, tea and coffee
Welcome and introduction
Symposium 3: Digital and computational pathology
Chair: Peter Bankhead
Computational pathology and QuPath
Dr Peter Bankhead, Senior Lecturer, Digital Pathology, Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh
A roadmap for the automation of duodenal biopsy diagnosis, with particular focus on Coeliac Disease
Dr Florian Jaeckle, Postdoctoral Research Associate, Computer Vision for Medical Imaging, University of Cambridge
Interpretable AI for precision histopathology
Presenting virtually: Professor Nasir Rajpoot, GSK Professor of Computational Pathology, University of Warwick
Tea and coffee break
Poster Viewing and Trade Exhibition
Education and trainee subcommittee symposium: Molecular pathology of non-neoplastic diseases
Chairs: Dr Abhik Mukherjee and Dr Caroline Cartlidge
Personalised medicine in non-neoplastic cardiovascular disease
Professor Mary Sheppard, Cardiac Pathologist, St George's University of London
Inflammatory bowel disease in children: Host-microbiota interaction
Professor Marta Cohen, Clinical Pediatric Pathologist, Histopathology Department, Sheffield Children's NHS Foundation Trust
Autophagy in neurodegenerative diseases
Professor David Rubinsztein, Professor of Molecular Neurogenetics, Cambridge Institute for Medical Research
Lunch
Poster Viewing and Trade Exhibition
Announcements
Golden Microscope Award and Paola Domizio Award
Rapid fire oral presentations and prize
Profiling the evolutionary history of giant cancer cells in undifferentiated pleomorphic sarcomas: Hopeful monsters or an evolutionary dead end?
Amy Bowes
Differentiation signals via Grainyhead-like transcription factor 3 induce expression of the DNA mutating enzyme APOBEC3A in healthy and cancerous epithelial cells: implications for somatic mutagenesis and drug resistance
Tim Fenton
Self-supervised AI guides discovery of morphologies associated with recurrence in lung adenocarcinoma
Kai Rakovic
Evolutionary dynamics of phenotypic plasticity in metastatic colorectal cancer
Maximilian Mossner
An investigation of polygenic risk scores for disease susceptibility and prognostic prediction in an inflammatory bowel disease cohort
Tejas Easwar
Symposium 4: Single cell and spatial transcriptomic approaches to cancer biology
Chairs: Professor Ming Du and Professor Gareth Thomas
Melanoma: Space is the place: relevance of spatial single cell analysis for the melanoma microenvironment
Dr Francesca Bosisio, Professor of Dermatopathology, Melanoma Researcher, KU Leuven, Belgium
Tumour microenvironment: Multiplexed imaging for pathology – challenges and opportunities
Dr Leeat Keren, Assistant Professor, Department of Molecular Cell Biology, Weizmann Institute of Science, Israel
Tea and coffee break
Poster Viewing and Trade Exhibition
Head and neck cancers: Dissecting the microenvironment of head and neck cancer using single cell RNA sequencing: Characterisation of fibroblast phenotype and function
Professor Gareth Thomas, Professor of Experimental Pathology, University of Southampton
Renal cancer: Uncovering the architecture of kidney cancer through spatial transcriptomics
Mr Thomas J Mitchell, Clinician Scientist, Consultant Urologist, Early Cancer Institute, University of Cambridge
Closing remarks
Close of meeting
Sponsors
Location
Royal Society of Medicine, 1 Wimpole St, Marylebone, London, W1G 0AE, United Kingdom
Registration for this event will close at 1:00am on 29 January 2024. Late registrations will not be accepted.
The agenda is subject to change at any time
If the event is recorded, we are only able to share presentations that we have received permission to share. There is no guarantee that all sessions will be available after the event, this is at the presenter’s and RSM’s discretion.
All views expressed at this event are of the speakers themselves and not of the Royal Society of Medicine, nor the speaker's organisations.
This event will be recorded and stored by the Royal Society of Medicine and may be distributed in future on various internet channels.